Annual Letters - Chan Zuckerberg Initiative

Chan Zuckerberg Initiative
In 2015, with the birth of their first daughter, Mark Zuckerberg and Priscilla Chan wrote a letter about the world they hoped she and all children would grow up in. In that letter, they also shared their plans to give 99% of their Meta (formerly Facebook) shares to help make that world a reality. Each year, the Chan Zuckerberg Initiative shares the lessons, milestones and impact of CZI’s work.
We’re highlighting a decade of bold bets across science, education and local communities — and the breakthroughs now emerging from sustained, long-term investment.
Discover how advances in AI are transforming biomedical research and enhancing education tools alongside our efforts to support communities and drive progress across our work.
Learn how we’re building for this moment. Our earliest bets in science paved the way for us to use artificial intelligence to unlock new scientific discoveries that will help cure, prevent, or manage all diseases by the end of this century. We also highlight the impact of our education work and share how we’re exploring new ways to leverage our grantmaking and technology capabilities to co-build tools with partners.
We are a community of builders. This community builds many things, from technologies to partnerships. We all share a deep motivation to learn, create and iterate together — because building collaboratively will help us unlock a better future.
We’ve been learning from our partners and working alongside them to build for breakthroughs, empowerment, and equity with new tools and collaborations. Now we’re ready to double down on our commitments that are showing the greatest potential to make an outsized impact — and accelerate progress toward a healthier, more equitable future.
Our CZI journey began five years ago, and this year especially — amidst the tremendous challenges facing our communities, from the longstanding inequities caused by systemic racism to new hardships inflicted by a global pandemic and economic crisis, we feel the urgent call to accelerate change. This year we reflect on our major milestones, how we can affect change together, and the lessons we’re learning along the way.
From the very beginning, CZI was rooted in family. It started with us and it’s grown to include hundreds of employees and partners around the world. Meet a few members of our CZI family — and celebrate the partnerships that are powering progress in science, education, justice and opportunity, and in lifting up local communities.
We are more optimistic about our journey than ever before — because we’re making real progress — alongside the entrepreneurs, scientists, teachers, advocates, and engineers who inspire us every day.
This year, see how two aspects of the Chan Zuckerberg Initiative — a long term approach of tackling challenges over decades and a technology mindset — shape our work. We believe there are answers to even the toughest problems.
Join a conversation with Mark, Priscilla, and our leadership team about our first year and what’s to come.
Dear Max, As you begin the next generation of the Chan Zuckerberg family, we also begin the Chan Zuckerberg Initiative to join people across the world to advance human potential and promote equality for all children in the next generation. Our initial areas of focus will be personalized learning, curing disease, connecting people and building strong communities.
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