Micro-Manager

μManager has a simple and clean user interface, expediting execution of common microscope image acquisition tasks such as time-lapses, multi-channel imaging, z-stacks, and combinations thereof.
μManager works with microscopes from all four major manufacturers (Leica, Nikon, Olympus and Zeiss), most scientific-grade cameras and many peripherals used in microscope imaging.
μManager is an open source project hosted on GitHub, developed and written by both software developers and users.